Preheat oven to 350 degrees F. Lightly grease a standard size loaf pan with cooking spray.
Add all of the meatloaf ingredients to a large bowl and gently mix everything to combine (without over-working the meat). Add the meat mixture to a loaf pan and gently pat into an even layer.
Bake for about 30 minutes. Meanwhile, make the meatloaf sauce by combining all ingredients in a bowl.
Remove meatloaf from oven and spread sauce on top. Return to oven for 10-20 minutes or until cooked through (160 degrees F).
Allow to rest for 10 minutes before slicing and serving.
Make Ahead Instructions: Make meatloaf and shape into loaf pan 1-2 days ahead of time. Cover and store in the refrigerator until ready to bake. Allow it to come to room temperature before baking. You can also make the meatloaf sauce several days ahead of time and store it in the refrigerator.Freezing Instructions:
Unbaked meatloaf: cover unbaked meatloaf with a layer of plastic wrap and aluminum foil. Freeze for up to 3 months. Thaw for about 24 hours in the refrigerator. Remove from the fridge and allow to come to room temperature before baking.
Baked meatloaf: Cut meatloaf into slices and allow to cool completely. Flash freeze slices on a baking sheet for one hour until semi frozen. Then place slices in a freezer safe bag in the freezer for up to 3 months. Thaw overnight in the fridge, then reheat in the microwave or oven.
Instant Pot MeatloafMini MeatloafHealthier meatloaf: substitute lean ground beef or half ground turkey/half ground beef.No loaf pan? No problem, simply form the meatloaf into the shape of a loaf and bake it on a baking sheet.Turkey Meatloaf: substitute ground turkey in place of ground beef.Stuffed Meatloaf: Prepare meatloaf mixture and press half into the bottom of the pan. Add cheese slices (your favorite kind of cheese), then cover with remaining meat mixture. Bake as directed.